HPV16与新疆维吾尔族食管鳞癌的相关性

Relationship between human papillomavirus 16 and esophageal squamous cell carcinoma in Uygur population in Xinjiang Uygur Autonomous Region

目的:调查新疆维吾尔族食管鳞癌患者中人乳头瘤状病毒(HPV)16型的感染率.方法:采用PCR技术检测82例新疆维吾尔族食管鳞癌和80例癌旁正常食管黏膜石蜡包埋组织HPV16的感染率,分析其与新疆维吾尔族食管鳞癌发生的关联性.结果:在新疆维吾尔族食管鳞癌组织中,HPV16型检出率为31.7%(26/82),与对照组12.5%(10/80)相比,差异有统计学意义(χ2=8.643,P<0.05);按照年龄、性别、病理分化程度及临床分期对维吾尔族食管鳞癌中的HPV16感染状况比较,差异均无统计学意义(χ2=0.301、0.149、2.876、0.105,均P>0.05).结论:HPV16型感染与新疆维吾尔族食管鳞癌的发生存在一定的相关性,但与患者的年龄、性别、病理分化程度及临床分期无明显的关联性.

AIM： To investigate the infection rate ofhuman papillomavirus 16 （HPV16） in Uygur patients with esophageal squamous cell carcinoma in Xinjiang. METHODS： Eighty-two paraffin-embedded specimens of esophageal carcinoma and 80 tumor-adjacent specimens were used in the study. The presence of HPV16 in these specimens was detected by high-sensitivity polymerase chain reaction （PCR） using the typespecifi c E6 primers. RESULTS： The infection rates of HPV16 in esophageal squamous cell carcinoma and tumoradjacent tissue were 31.7% （26/82） and 12.5% （10/80）, respectively, showing signif icant difference between the two groups. HPV16 infection was not correlated with patient’s age and sex as well as pathological differentiation and clinical stage of the carcinoma （χ2 = 0.301, 0.149, 2.876 and 0.105, respectively; all P 〉 0.05）. CONCLUSION： HPV 16 infection is possibly correlated with esophageal squamous cell carcinoma in Uygur population in Xinjiang but showed no correlation with patient’s age and sex as well as pathological differentiation and clinical stage of the carcinoma.