传统开腹与腹腔镜胆囊切除术对患者肝功能和免疫功能变化的影响的比较

Changes in liver function and immune function following laparoscopic and traditional open cholecystectomy: a comparative study

目的比较传统开腹胆囊切除术(OC)与腹腔镜胆囊切除术(LC)对患者肝功能和免疫功能的影响。方法选择胆囊良性病变且肝功能正常需行胆囊切除术者,按患者对手术方案的意愿分别行OC和LC(各21例),分别在术前1d、术后第7天测定肝功能指标(包括ALT、AST、TBIL、ALB)和免疫功能指标(包括CD3、CD4、CD8、NK细胞的百分比、免疫球蛋白IgA、IgM、IgG及补体C3、C4含量),对两组各项指标的术后与术前的差值行非配对t检验。结果两组的各项指标的术后与术前的差值差异均无统计学意义。结论LC与OC对患者肝功能和免疫功能的影响无明显差异。

Objective To compare the effect of laparoscopic cholecystectomy （LC） and open cholecystectomy （OC） on liver function and immune function. Methods Forty-two patients with normal liver function underwent LC （n=21） or OC （n=21） according to the patients＇ preference. One day before and 7 days after the operations, the liver functions （ALT, AST, TBIL, ALB） and immune functions （CD3, CD4, CD8, NK cell percentage, IgA, IgM, IgG and C3, C4） of the patients were measured. Results No statistical differences were found in the liver functions or immune functions between the two groups after the operation. Conclusion LC and OC show no significant difference in the effects on the liver function and immune function.