2型糖尿病患者大血管病变临床相关因素的探讨

Study on macrovascular lesion related clinical factors in type 2 diabetes mellitus patients

目的:探讨2型糖尿病(2-DM)患者发生大血管病变的临床相关因素及其与微血管病变的关系。方法:根据有无大血管病变将189例2-DM患者分为2-DM合并大血管病变组(97例)和2-DM无大血管病变组(92例),2组间无性别及年龄差异(P>0.05),分析2组患者的临床指标及微血管病变发生的情况。结果:2-DM合并大血管病变组患者尿素氮(BUN)水平、肌酐(SCr)水平、尿酸(UA)水平以及颈动脉内中膜厚度(C-IMT)和微血管病变发生率均高于2-DM无大血管病变组患者,其肾小球滤过率(GFR)则低于2-DM无大血管病变组患者,差异均有统计学意义(P<0.01)。Logistic回归分析提示2-DM患者合并大血管病变的危险因素为UA、GFR、C-IMT。结论:2-DM患者发生大血管病变与UA升高、GFR下降、C-IMT增厚有关,大血管病变与微血管病变之间可能存在相关关系。

Objective To analyze the clinical factors related to macrovascular lesion and its correlation with mierovascular lesion in type 2 diahetes mellitus （2-DM）. Methods A total of 189 2-DM patients were enrolled. These patients were divided into two groups： with maerovascular lesion group （n=97） and without maerovascular lesion group （n= 92）. No difference in gender and age was found between these two groups. The clinical factors and the incidence of mierovascular lesion in these two groups were analyzed. Results Compared with the group without maerovaseular lesion, blood urea nitrogen （BUN） level, serum ereatinine （SCr） level, uric acid （UA） level and incidence of mierovaseular lesion, carotid intima-media thickness （C-IMT） inerassation were significantly higher in group with maerovaseular lesion （P〈0.01）, while the glomerular filtration rate （GFR） was significantly lower （P〈O.OI）. Logistic regression analysis showed that UA, GFR, C-IMT were the risk factors of maerovaseular lesion in 2-DM patients （P〈0.05）. Conclusions The occuring of macrovasular lesion in 2-DM patients is related to UA, GFR, C-IMT and there may be some correlation between maerovaseular and mierovaseular lesions.