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霉酚酸酯对器官移植受者次黄嘌呤核苷酸脱氢酶活性的影响 被引量:3

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摘要 霉酚酸酯(mycophenolate mofetil,MMF)作为一种高特异性的淋巴细胞抑制剂已广泛应用于各种实体器官的移植。MMF经胃肠道吸收入血并迅速水解为活性成分霉酚酸(mycophenolic acid,MPA),大部分MPA和血浆蛋白结合,少量以游离形式发挥免疫抑制作用。
作者 茅华荣 陈皓
出处 《诊断学理论与实践》 2009年第6期662-664,共3页 Journal of Diagnostics Concepts & Practice
基金 上海自然科学基金项目资助(08ZR1414200)
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  • 1Port FK, Merion RM, Goodrich NP, et al. Recent trends and results for organ donation and transplantation in the United States, 2005[J]. Am J Transplant, 2006, 6(5 Pt 2): 1095-1100.
  • 2Nowak I, Shaw LM. Effect of mycophenolic acid glucuronide on inosine monophosphate dehydrogenase activity [J]. Ther Drug Monit, 1997, 19(3): 358-360.
  • 3Picard N, Ratanasavanh D, Premaud A, et al. Identification of the UDP-glucuronosyhransferase isoforms involved in mycophenolic acid phase II metabolism [J]. Drug Metab Dispos, 2005, 33(1): 139-146.
  • 4Bowalgaha K, Miners JO. The glucuronidation of mycophenolic acid by human liver, kidney and jejunum microsomes [J]. Br J Clin Pharmacol, 2001, 52(5): 605-609.
  • 5Hood KA, Zarembski DG. Mycophenolate mofetil: a unique immunosuppressive agent [J]. Am J Health Syst Pharm, 1997, 54(3): 285-294.
  • 6Staatz CE, Tett SE. Clinical pharmacokinetics and pharmacodynamics of mycophenolate in solid organ transplant recipients [J]. Clin Pharmacokinet, 2007, 46(1): 13-58.
  • 7Weimert NA, Derotte M, Alloway RR, et al. Monitoring of inosine monophosphate dehydrogenase activity as a biomarker for mycophenolic acid effect: potential clinical implications [J]. Ther Drug Monit, 2007, 29(2): 141-149.
  • 8McPhillips CC, Hyle JW, Reines D. Detection of the mycophenolate-inhibited form of IMP dehydrogenase in vivo [J]. Proc Natl Acad Sci U S A, 2004, 101(33): 12171- 12176.
  • 9Blaheta RA, Leckel K, Wittig B, et al. Inhibition of endothelial receptor expression and of T-cell ligand aetivity by myeophenolate mofetil[J]. Transpl Immunol, 1998, 6 (4): 251-259.
  • 10Natsumeda Y, Ohno S, Kawasaki H, et al. Two distinct cDNAs for human IMP dehydrogenase [J]. J Biol Chem, 1990, 265(9): 5292-5295.

同被引文献19

  • 1Chen L, Pankiewicz K W. Recent development of IMP dehydrogenase inhibitors for the treatment of cancer[J]. Curt Opin Drug Discov Devel, 2007, 10 (4): 403-412.
  • 2Krzysztof W P. Inhibitors of inosine monophosphate dehydrogenase as potential chemotherapeutic agents[J]. Expert Opin Ther Pat, 2001,11(7): 1161-1170.
  • 3Hedstrom L, Gan L. IMP dehydrogenase: structural schizophrenia and an unusual base[J]. Curr Opin Chem Biol, 2006, 10(5): 520-525.
  • 4Gilpin M L, Box S J, Elson A L. New quinine antibiotics of the granaticin type,isolated from streptomyces lateritius. II .Strcture determination[J]. JAntibiot, 1988, 41(4): 512-518.
  • 5Bentley R. Mycophenolic acid: a one hundred year odyssey from antibiotic to immunosuppressant[J]. Chem Rev, 2000, 100(10): 3801-3826.
  • 6Chen L, pankiewicz K W. Recent development of IMP dehydrogenase inhibitors for the treatment of cancer[J]. Curt Opin Drug Discov Devel, 2007, 10(4): 403-412.
  • 7Watkins W J, Chen J M, Cho A, et al. Phosphonic acid- containing analogues of mycophenolic acid as inhibitors of IMPDH[J]. BioorgMed Chem Lett, 2006, 16(13): 3479-3483.
  • 8林洁,可爱兵,张雪莲,郑智慧,朱京童,路新华,李业英,崔晓兰,石英,张华,贺建功.微生物来源的次黄嘌呤一磷酸盐脱氢酶抑制剂2264 A和B的研究[J].中国抗生素杂志,2008,33(8):463-466. 被引量:4
  • 9栗若兰,郑智慧,路新华,张雪霞,董爱华,段宝玲,赵宝华.霉酚酸对人结肠癌SW620细胞凋亡的诱导作用及其机制[J].河北师范大学学报(自然科学版),2013,37(5):519-523. 被引量:2
  • 10于立新,周敏捷,罗敏.肾移植受者应用霉酚酸酯的合理治疗窗[J].南方医科大学学报,2014,34(12):1842-1845. 被引量:7

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