第10个溶质转运蛋白家族(SLC10)的细胞功能

Cellular Functions of the Solute Carrier Family 10(SLC10)

溶质转运蛋白(solute carrier,SLC)是细胞内最大的一类转运蛋白,目前被分为55个家族,包括至少362个成员。这里介绍了第10个溶质转运蛋白家族(SLC10)各成员的鉴定、表达和功能方面的研究进展,并对该家族成员顶端钠依赖性胆汁酸转运蛋白(apical sodium-dependent bileacid transporter,ASBT)和Na^+/牛磺胆酸共转运多肽(Na^+/taurocholate cotransporting polypeptide,NTCP)的底物特异性及其抑制剂在药物开发方面的研究做了简要介绍。对SLC10的功能研究可以为治疗高胆固醇血症新药的开发提供理论指导,也可以为人类一些与SLC10突变相关的其他疾病的诊断和治疗开辟新的途径。

The solute carrier （SLC） superfamily is the largest class of cellular transporters and could be divided into 55 families with at least 362 members. Here, we reviewed the research progresses in the identification, expression and functions of the solute carrier family 10 （SLC10） members. In addition, the substrate specificity as well as the inhibitors and their potentials as pharmaceutical drugs of apical sodium-dependent bile acid transporter and Na^＋/taurocholate cotransporting polypeptide, two members of the SLC10 family, is briefly discussed. Functional studies on the SLC 10 carriers would provide a basis for drug development against human diseases related to the SLC10 family members.