破骨细胞研究进展

Progress in Osteoclast

破骨细胞起源于造血干细胞,主要功能是进行骨吸收,在骨重塑中起着重要的调节作用。破骨细胞的形成和活性异常可引起一系列骨骼疾病,因此,近年来破骨细胞已成为骨骼疾病研究的靶细胞,同时,它也是失重环境中骨丢失发生机制研究的热点,本文就破骨细胞的分化、功能及其功能异常产生的影响等方面研究内容进行综述。

The osteoclast is originated from hemopoietic stem cell and plays a key role in bone remodelling. Changes of its formation and activation will result in a series of bone diseases.Osteoclasts have become the target of studies on bone diseases and the focus of the investigation about how weightlessness causes bone loss.The differentiation,function of osteoclasts and the effects of osteocalsts dysfunction were summarized.