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Th17细胞亚群与病毒感染性疾病 被引量:1

Th17 cells and viral infectious diseases
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摘要 近年来,新的独立的细胞亚群——Th17细胞的发现,打破了传统的Th1/Th2细胞分化模式。Th17细胞亚群因其在多种人类炎症性疾病中的重要作用而备受关注,而Th17细胞在病毒感染性疾病中的作用仍存争议。此文就目前Th17细胞亚群与常见病毒感染性疾病的最新研究进展进行综述。 Recently, the Th1/Th2 dichotomy has been revisited by the new member of the CD4^+ Th cells family, now widely known as Th17 cells. Th17 ceils have attracted much attention as a consequence of their important roles in several models of human inflammatory disorders. But the role of Th17 cells in viral infectious diseases is still controversial. The focus of this article is to review the emerging studies on the role of Th17 cells during viral infectious diseases.
作者 李婕 陈智
出处 《国际流行病学传染病学杂志》 CAS 2009年第6期395-398,共4页 International Journal of Epidemiology and Infectious Disease
基金 国家973计划项目(2007CB512905) 国家自然科学基金(30771918) 国家“十一五”重大专项课题(2008ZX10002-007)
关键词 白细胞介素17 TH17细胞 病毒性疾病 IL-17 Th17 cells Viral diseases
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参考文献23

  • 1Wei L,Laurence A,Elias KM,et al.IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner.J Biol Chem,2007,282(48):34605-34610.
  • 2Chen Y,Langrish CL,McKenzie B,et al.Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis. J Clin Invest,2006,116(5):1317-1326.
  • 3Oboki K, Ohno T, Saito H, et al. Th17 and allergy. Allergol Int, 2008, 57(2) : 121-134.
  • 4Kikly K, Liu L, Na S, et al. The IL-23/Th ( 17)axis: therapeutic. targets for autoimmune inflammation. Curr Opin Immunol, 2006, 18 (6) :670-675.
  • 5Kleinschek MA,Owyang AM,Joyce-Shaikh B,et al.IL-25 regulates Th17 function in autoimmune inflammation.J Exp Med, 2007, 204 ( 1 ) : 161-170.
  • 6Yen D, Cheung J, Scheerens H, et al. IL-23 is essential for T cell- mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest, 2006, 116(5) : 1310-1316.
  • 7Kom T, Bettelli E, Gao W, et al. IL-21 initiates an alternative pathway to induce proinflammtory T(H)17 cells. Nature, 2007, 448 (7152) :484-U489.
  • 8Lohr J,Knoechel B,Wang JJ,et al.Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease. J Exp Med, 2006, 203(13) :2785-2791.
  • 9Ichiyama K, Yoshida H, Wakabayashi Y, et al. Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat. J Biol Chem, 2008, 283( 25 ) : 17003- 17008.
  • 10Veldhoen M, Hocking R J, Atkins C J, et al. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells, Immunity. 2006, 24(2):179-189.

同被引文献17

  • 1丙型肝炎防治指南[J].临床肝胆病杂志,2004,20(4):197-203. 被引量:735
  • 2HONORATI M C, NERI S, CATFINI L, et al. Interleukin- 17, a regulator of angiogenic factor release by synovial fi- broblasts [ J ]. Osteoarthritis Cartilage, 2006,14 (4) : 344 - 352.
  • 3WONG C K, LIT L C, TAN L S, et al. Hyperproduetion of IL-23 and IL-17 in patients with systemic lupus erythe- matous:implication for Thl7- mediated inflammation in auto-immunity [ J ]. Clin Immunol, 2008,127 (3):385 - 393.
  • 4SCHNYDER-CANDRIAN S ,TOGBE D, COUILLIN I,et al. Interleukin-17 is a negative regulator of established allergic asthma [ J ]. J Exp Med, 2006,203 ( 12 ) : 2 715 - 2 725.
  • 5YASUMI Y,TAKIKAWA Y,ENDO R,et al. Interleukin- 17 as a new marker of severity of acute hepatic injury [J]. Hepatology Research, 2007,37 (4) : 248- 254.
  • 6ARNAUD L, CHRISTOPHE M. The Interleukin- 17 path- way is involved in human alcoholic liver disease [J].Hepatology, 2009,49 ( 2 ) : 646- 657.
  • 7WEI W U,JIE L I,FENG CHEN,et al. Circulating Th17 cells frequency is associated with the disease progression in HBV infected patients [J]. Gastroenterol Hepatol, 2010,25(4) :750-757.
  • 8JING-PING Z,JING Y. Increased intratumoral IL-17 producing cells correlate with poor survival in hepatocellu- lar carcinoma patients [J]. Journal of Hepatology, 2009,50(3) :980-989.
  • 9WEAVER C T, HATrON R D, MANGAN P R, et al. IL- l7 family cytokines and the expanding diversity of effector T cell lineages [ J ]. Annu Rev Immunol, 2007,25 (8):21 - 852.
  • 10VELDHOEN M, HOCKING R J, ATKINS C J, et al.TGF- Beta in the context of an inflammatory eytokine milieu sup- ports de novo differentiation of IL-17-produeing T cells[ J ]. Immunity, 2006,24 ( 8 ) : 179- 189.

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