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老年慢性心力衰竭患者血清肿瘤坏死因子-α及脑钠肽水平与左室功能的相关性研究 被引量：3

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摘要 目的探讨慢性心力衰竭(CHF)患者血清肿瘤坏死因子-α(TNF-α)及脑钠肽(BNP)水平与左室功能的相关性。方法采用ELISA方法测定50例老年CHF患者和50例老年健康对照者血清TNF-α和BNP浓度,采用超声心动图检查受试者左心室参数。结果CHF组血浆TNF-α和BNP浓度均高于对照组,且随着心力衰竭程度的加重而显著增加(P<0.05);CHF组血浆TNF-α和BNP浓度分别与左心室舒张末内径呈正相关(P<0.05),而与左心室射血分数及左心室短轴缩短率呈负相关(P<0.05),并且TNF-α与BNP之间呈显著正相关(P<0.05)。结论血清TNF-α在CHF的发展中起重要作用,联合检测TNF-α与BNP有助于判断CHF病情的严重程度,有效抑制炎性细胞因子水平有望成为治疗CHF的新手段。
作者 于海利 徐淑敏 徐淑清
机构地区 长春市人民医院循环内科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2009年第24期3197-3198,共2页 Chinese Journal of Gerontology
关键词 慢性心力衰竭 肿瘤坏死因子-Α 脑钠肽 左室功能
分类号 R541.61 [医药卫生—心血管疾病]
  • 相关文献

参考文献11

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二级参考文献1

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共引文献2475

同被引文献31

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引证文献3

二级引证文献16

中国老年学杂志
2009年 第24期

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