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Exendin-4对2型糖尿病大鼠胰岛β细胞增殖的影响 被引量：1

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摘要 目的观察Exendin-4对链脲佐菌素(STZ)造模糖尿病(DM)大鼠的空腹血糖(FBG)、胰岛功能及胰岛β细胞增殖数目表达的影响。方法SD大鼠高脂喂养结合小剂量腹腔注射STZ(35mg/kg),制备2型糖尿病(T2DM)大鼠模型,随机分成DM组及Exendin-4治疗低、中、高剂量组,并设立正常对照组,Exendin-4给药6w后处死大鼠,心脏取血测FBG、糖化血红蛋白(HbA1c)、胰岛素,取胰腺组织切片作HE染色,胰岛素抗体免疫组化、增殖细胞核抗原染色(PCNA),计算胰岛β细胞增殖率。结果Exendin-4各剂量组胰岛素表达阳性的β细胞增殖率较DM组增加(P<0.01);Exendin-4高剂量组与DM组比较,FBG和HbA1c水平明显降低(P<0.01)。血清胰岛素增加,中、低剂量组之间无统计学差异但与DM组有统计学差异。结论Exendin-4能够促进DM大鼠胰岛β细胞增殖,改善血糖代谢和胰岛素抵抗。
作者 范爱红 李伟
机构地区 淮安市妇幼保健院内科 徐州医学院附属医院内分泌科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2009年第24期3219-3221,共3页 Chinese Journal of Gerontology
关键词 EXENDIN-4 糖尿病 胰岛Β细胞 增殖率
分类号 R587.2 [医药卫生—内分泌]
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参考文献9

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二级参考文献23

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中国老年学杂志
2009年 第24期

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