妊娠期甲亢治疗情况对子代预后的影响

Effects of the therapy for maternal hyperthyroidism during pregnancy on the prognosis of offspring

目的:探讨孕妇妊娠合并甲状腺功能亢进症(甲亢)对子代预后的影响。方法:选取2004年1月至2007年12月在我院出生,母妊娠合并甲亢的新生儿52例,根据孕妇甲亢治疗情况分为甲亢治疗组(41例)与未治疗组(11例),对两组甲亢孕妇所分娩的婴儿甲状腺功能与生长发育进行随访、分析。结果:未治疗组中,新生儿甲亢发生率为36.4%(4/11),甲状腺功能减低症发生率为45.5%(5/11),早产儿发生率为54.5%(6/11),小于胎龄儿发生率为18.2%(2/11)。而治疗组中,新生儿甲亢发生率为2.4%(1/41),早产发生率为9.8%(4/41),未发生甲状腺功能减低症和小于胎龄儿。两组在婴儿甲状腺功能异常、早产及小于胎龄儿发生率上差异均有显著性(P<0.05)。结论:母孕期甲亢未治疗者婴儿甲状腺功能异常、早产及小于胎龄儿发生率升高。合理治疗妊娠期甲亢对改善子代预后有积极意义。

Objective：To explore the effect of maternal hyperthyroidism during pregnancy on their offspring.Methods：The clinical data of 52 neonates of mothers with hyperthyroidism were reviewed.According to the maternal hyperthyroidism therapy,infants were divided into two groups：treated maternal hyperthyroidism group（41 infants） and un-treated group（11 infants）.The thyroid function and growth in the two groups were analyzed.Results： The incidences of neonatal hyperthyroidism,neonatal hypothyroidism,premature infant in un-treated group were 36.4%, 45.5%, 54.5% and 18.276, respectivey, the inckidences of those in the treated group were 2.4%, 0, 9.8% and 0, respectively. The difference was statistically significant （P〈0.05） in two groups of abnormal function of thyroid, premature infant and small for gestational age infant. Conclusion： In the infants of un-treated maternal hyperthyroidism, the rates of neonatal abnormal thyroid function, premature, and small for gestational age infant are increased.Treated maternal hyperthyroidism can improve the prognosis of offspring.