口服小剂量西地那非治疗早泄疗效研究

Study of daily low-dose Sildenafil on the curative effects in patients by premature ejaculation

目的:评估持续口服小剂量西地那非、佐洛复、百优解治疗早泄及停药后的疗效。方法:191例早泄病人随机归入3组,接受为期3个月的西地那非、佐洛复、百优解治疗。记录各组病人在治疗前、治疗后以及治疗停药2个月、3个月中国早泄指数评估表(CIPE)评分及性双方对性生活的满意程度。比较各组及组间在各阶段的CIPE评分。结果:3组对象治疗前CIPE分别为(20.77±2.77)、(20.92±2.80)和(20.98±2.53)分,差异无显著性(P>0.05);治疗3个月后分别为(39.22±4.56)、(37.53±3.76)和(37.66±3.63)分;停药2个月后为(31.24±5.25)、(22.85±5.67)和(22.47±4.64)分。停药3个月后西地那非组CIPE为(27.26±5.24)分。3组病人药物治疗3个月后CIPE较治疗前均有显著性升高(P<0.01)。组间除佐洛复组与百忧解组差异无显著性外,西地那非组与其它两组间差异均有显著性(P<0.05)。药物治疗后,3组对象夫妻性生活满意度明显改善,从高到低依次为:西地那非组、百忧解组、佐洛复组。西地那非组停药2个月后与治疗前CIPE差异有显著性(P<0.05);停药3个月后CIPE仍高于治疗前基线水平,41.5%病人仍具有较好疗效。佐洛复组及西地那非组停药2月后CIPE显著降低,大部分病人症状复发,退出研究,无法继续随访。结论:每日口服小剂量西地那非能有效治疗早泄。在效果上,好于左洛复和百忧解,每日口服小剂量西地那非在治疗停药后大部分病人疗效可达2个月以上。

Objective：To evaluate the curative effects of low-dose Sildenafil,Sertraline and Fluoxetine for patients with premature ejaculation（PE）,and to observe the effects in each treatment group after drug withdrawl.Methods：A total of 191 PE patients met our study criteria was divided randomly into three groups and then received 3-month treatment of Sildenafil,Sertraline and Fluoxetine,respectively.The curative effects in each group of patients before treatment,after treatment and after withdrawl of 2 months and 3 months using the methods of Chinese index of sexual function for premature ejaculation （CIPE） and the sex life satisfactory degree from both sides were recorded and compared. Results： Before treatment, there was no significant difference of CIPE among Sildenafilgroup, Sertraline-group and Fluoxetine-group （20.77 ± 2.77,20.92 ± 2.80 and 20.98 ± 2.53,respectively）. After 3-month treatment, the CIPE was 39.22±4.56, 37.53±3.76and 37.66±3.63 respectively and 2months after drug withdrawal, the CIPEwas 31.24±5.25, 22.85± 5.67 and 22.47± 4.64 respectively. There was positive difference of CIPE between pre-treatment and post treatment in each group （P〈0.01）. In addition, The significant difference between Sildenafil-group and other two groups after 3-month treatment was also observed. However, the differences between Sertraline-group and Fluoxetine-group could not be found. As to the sex life satisfactory degree, the patients of three groups all improved obviously after treatment, the results as follows： Sildenafil-group 〉 Fluoxetine-group 〉 Sertralinegroup. Compared to other two groups, the Sildenafil-group patients still had effects in 3 months after drug withdrawal. Most patients, however, withdrew from the study because of recurrence after durg withdrawal. Conclusion： Low-dose Sildenafil is effective treatment for PE. The effect of Sildenafil is much better than Sertraline and Fluoxetine. Furthermore, the curative effect of Sildenafil can also maintain more than 2 months after drug withdraw among most PE patients.