心脏型脂肪酸结合蛋白在早期急性心肌梗死诊断中的价值

Significance of heart-type fatty acid binding protein in diagnosis of early acute myocardial infarction

[目的]研究血浆心型脂肪酸结合蛋白（H-FABP）在早期急性心肌梗死（AMI）诊断中的价值。[方法]选择2008年5月~2008年12月因胸痛就诊于大连医科大学附属第一医院,被确诊为急性心肌梗死的患者为对象,共收集27例,选择正常对照50名,为体检健康者。采用免疫胶体金渗透方法定性检测正常对照和急性心梗患者发病3 h内血浆的H-FABP,并与心肌肌钙蛋白I（cTnI）、肌酸激酶同工酶质量（MMB）和肌酸激酶（CK）的检测结果进行比较。[结果]H-FABP在急性心梗病人发病3 h内诊断早期AMI的阳性率（96%）明显高于cTnI（68%）、MMB（23%）和CK（24%）（P〈0.05）。[结论]H-FABP对于诊断早期AMI具有较高的敏感性和良好的特异性,其对早期急性心肌梗死的诊断敏感性优于cTnI、MMB、CK。

[ Objective] To study the value of heart-type fatty acid binding protein （H-FABP） in the diagnosis of early acute myocardial infarction （AMI） . [ Method ] The plasma level of H - FABP was measured by sandwich ELISA in 27 patients with suspected AMI at admission within 3 hours after onset of chest pain and 50 normal healthy subjects. The plasma rations of cardiac troponin- I （cTnI）, the quality of creatine kinase isoenzyme-MMB and creation phospholinase （CK） were assayed at the same time by using automatic biochemical analyzer. [ Result] The diagnostic positive rate （96%） of H - FABP for AMI within 3 hours after onset of chest pain, was significantly higher than that of cTnl （68 % ）, MMB （23 % ）, CK（24% ） （P 〈0.05）. [ Conclusion] H- FABP seems to be a useful biochemical cardiac marker for AMI in the early stage.