神经元轴突再生相关基因的作用机制

Mechanisms of gene action involved in axonal regeneration

神经损伤后神经元轴突再生的机制是目前研究的热点,而与轴突再生的相关基因的研究为阐明轴突的再生机制提供了分子生物学的重要依据。本文着重概述了GAP-43、BDNF、SPRR1A、Reg-2等基因参与并调节了轴突再生的过程,并探讨了其发挥作用的相关机制。

The molecular mechanisms of axonal regeneration after nerve injury is the hot spot of current research, and the investigation of axonal regeneration - associated genes has provided an important basis of molecular biology for mechanisms of axonal regeneration. Regeneration- associated genes as GAP- 43, BDNF, SPRR1A and Reg- 2 reviewed in this article have been identified to participate and regulate the process of axonal regeneration. The mechanisms of their action are discussed.