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结直肠癌与DNA甲基化 被引量：1

Colorectal carcinoma and DNA methylation
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摘要 表观遗传调控是真核基因的表达调控之一,在结直肠癌的发生发展中具有重要作用。DNA甲基化修饰是表观遗传调控中目前研究较多的部分,DNA甲基化异常引起抑癌基因失活和癌基因激活是结直肠癌形成的分子机制之一。DNA异常甲基化的逆转可能有助于结直肠癌的诊断和治疗。 Epigenetic regulation involved in eukaryotic gene expression plays an important role the progression of colorectal cancer. Colorectal cancer epigenetics is evolved in DNA methylation which is associated with the activation of oncogene and inactivation of tumor suppressor gene. The potential reversibility of DNA methylation offers exciting opportunities for therapy and diagnosis of colorectal carcinoma.
作者 刘敏姬 沈守荣
机构地区 中南大学湘雅三医院消化内科
出处 《中南大学学报（医学版）》 CAS CSCD 北大核心 2009年第12期1266-1270,共5页 Journal of Central South University ：Medical Science
基金 国家重点基础研究发展计划(973)(2006CB910503)~~
关键词 结直肠癌 表观遗传学 DNA甲基化 colorectal neoplasm epigenetics DNA methylation
分类号 R735.3 [医药卫生—肿瘤]
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参考文献40

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同被引文献8

  • 1周平坤 夏寿萱.真核基因损伤修复和基因表达的辐射兴奋效应[J].国外医学．放射医学核医学分册,1996,20(5):223-226.
  • 2Braendengen M, Tveit KM, Berglund A, et al. Randomized phase Ⅲ study comparing preoperative radiotherapy with chemo- radiotherapy in nonresectable rectal cancer. J Clin Oncol, 2008, 26(22) : 3687-3694.
  • 3Livak KJ, Schmittgen TD. Analysis of relative gene expression data using realtime quantitative PCR and 2 (-Delta Delta C(T)) Method. Methods, 2001,25 (4) : 402-408.
  • 4Navenot JM, Fujii N, Peiper SC. KISS1 metastasis suppressor gene product induces suppression of tyrosine kinase receptor signaling to Akt, tumor necrosis factor family ligand expression, and apoptosis. Mol Pharmacol, 2009,75(5) : 1074-1083.
  • 5Adell G, Zhang H, Jansson A, et al. Decreased tumor cellproliferation as an indicator of the effect of preoperative radiotherapy of rectal cancer. Int J Radiat Oncol Biol Phys, 2001,50 (3) :659-663.
  • 6Dunne AL, Price ME, Mothersill C, et al. Relationship between clonogenic radio-sensitivity, radiation induced apoptosis and DNA damage/repair in human colon cancer cells. Br J Cancer, 2003,89(12) :2277-2283.
  • 7顾晋.从个体化角度探讨直肠癌的治疗策略[J].中华胃肠外科杂志,2010,13(4):239-241. 被引量：11
  • 8林素勇,戴起宝,陈绍勤.Kissl蛋白及其受体GPR54在结直肠癌中表达的意义[J].肿瘤研究与临床,2010,22(6):406-409. 被引量：13

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中南大学学报（医学版）
2009年 第12期

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