动脉化疗栓塞治疗晚期卵巢癌

Intra-arterial Chemo-embolization in the Treatment of Advanced Ovarian Cancer

目的探讨经动脉化疗栓塞治疗晚期卵巢癌的疗效。资料与方法对48例晚期卵巢癌患者行髂内动脉、卵巢动脉化疗栓塞,其中Ⅲ期26例、Ⅳ期22例,灌注药物剂量分别为:顺铂(DDP)50mg/m2或卡铂400～600mg、丝裂霉素(MMC)6～10mg。栓塞剂选用明胶海绵。在介入术前3h静脉注射5-氟尿嘧啶(5-FU)1000～1250mg。结果采用单纯介入治疗者总有效率69.2%(9/13),完全缓解(CR)4例,部分缓解(PR)5例,稳定(SD)3例,进展(PD)1例,患者2年生存率46.2%(6/13)。采用介入+手术治疗者总有效率91.4%(32/35),CR21例,PR11例,SD3例,患者2年生存率71.4%(25/35)。无严重并发症发生。结论经导管动脉化疗栓塞治疗晚期卵巢癌疗效肯定,为综合治疗晚期卵巢癌增加了新的治疗手段,并为无法手术者提供了二期手术机会。

Objective To study the effect of intra-arterial chemo-embolization in the treatment of advanced ovarian cancer. Materials and Methods The interventional therapy was performed in 48 patietns with advanced ovarian cancer. 26 cases were in stage Ⅲ,22 cases were in stage Ⅳ. The drug dose was DDP 50mg/m2 or CBP 400-600mg,MMC 6-10mg. the embolic agent was gelfoam. 5-FU 1000-1250mg was given through intervenous drip three hours before the interventional therapy. Results Among the recurrent cancer （4CR,5PR,3SD,1PD）,the overall responserate （RR） was 69.2% （9/13） ,2-year survival rate were 38.5%. Among the primar？ cancer （21CR,11PR,3SD） ,the overall responserate （RR） was 91.4% （32/35） ,2-year survival rate was 71.4%. Nonhematopoietic toxicities were mild and tolerable. Conelusion Transcathter superselective chemo-embolization has appositive effect on advanced ovarian cancer. It has provided a new method for the comprehensive treatment of advanced ovarian cancer, and it wll give operable chance for the patient wbo were not suitable primarily with surgery.