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自分泌运动因子及其受体与神经系统的关系研究进展 被引量：3

Research progress in the relationship of autocrine motility factor,autocrine motility factor receptor and the nervous system
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摘要 自分泌运动因子(autocrine motility factor,AMF)能刺激细胞的迁移和运动,与肿瘤发生、转移、血管生成密切相关。近年来人们发现有3种AMF:ATX-t、ATX-m和PD-Ialpha,其中PD-Ialpha在脑中特异表达,在神经发育、生长和神经分化、神经外伤修复与神经性疼痛以及神经退行性疾病中具有重要的作用,提示AMF及其受体与神经系统的病理生理过程密切相关。该文就AMF及其受体在神经系统中的作用和作用机制作一综述,为相关的研究提供参考。 Autocrine motility factor （AMF） plays an important role in the stimulation of the migration and motility of cells,especially the generation,migration and angiogenesis of tumor.Recently,it has been found that AMF has three isoforms,ATX-t,ATX-m and PD-I alpha.The PD-I alpha isoform is specifically expressed in the brain,which plays extensive functions in nervous system,such as regulating neural development and differentiation,promoting neurotrauma repair,inducing neuropathic pain,even contributing neurodegeneration under some circumstances.This indicates the close relationship of AMF/AMFR and the pathophysiology of the nervous system.This paper mainly reviews the function of AMF and AMFR and its possible mechanism in the nervous system.
作者 邵璇 迟晓丽 周文霞 张永祥
机构地区 军事医学科学院毒物药物研究所
出处 《中国药理学通报》 CAS CSCD 北大核心 2009年第12期1541-1545,共5页 Chinese Pharmacological Bulletin
基金 国家重点基础研究发展计划(973计划)资助项目(No2004CB518907) 国家高技术研究发展计划(863计划)资助项目(No2008AA02Z423) 国家自然科学基金资助项目(No30600760 90709012 30772562)
关键词 自分泌运动因子 自分泌运动因子受体 磷酸二酯酶-Ialpha 神经退行性疾病 MORFO结构域 阿尔采末病 autocrine motility factor autocrine motility factor receptor PD-I alpha neurodegeneration MORFO domain Alzheimer s Disease
分类号 R-05 [医药卫生] R322.8 [医药卫生—人体解剖和组织胚胎学]
  • 相关文献

参考文献28

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共引文献13

同被引文献29

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引证文献3

二级引证文献11

中国药理学通报
2009年 第12期

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