摘要
研究从发酵液中提取美伐他汀的工艺条件。通过单因素实验确定了从美伐他汀发酵液中提取美伐他汀的最佳工艺条件。结果表明,醋酸丁酯作为提取溶剂时,其最佳工艺条件如下:提取温度为50℃,物料比(醋酸丁酯体积(mL):菌丝质量(g))为8:1,提取时间为3 h,闭环温度为70℃,闭环时间为6 h。本工艺简便,收率高,适用于工业化生产。
The process conditions of mevastatin extraction from mevastatin fermentation are studied. Through single factor test, the optimal conditions are determined. The results show that butyl acetate as extracting solvent requires the best technology conditions： temperature 50 ℃, ratio（butyl acetate volume/mL： mycelium weight/g）8 ： 1, time of extracting 3 hours, temperature of ring closed 70℃ ,and time of ring closed 6 hours. This process is simple, of high yield, and suitable for industrial manufacture.
出处
《河北工业科技》
CAS
2010年第1期35-37,40,共4页
Hebei Journal of Industrial Science and Technology
关键词
美伐他汀
发酵液
提取
mevastatin
fermentation
extraction
