45例肾病综合征患者肾组织c-Jun和c-Fos的表达及意义

Expression and significance of c-Jun and c-Fos in 45 patients with nephrotic syndrome

目的探讨肾病综合征激素抵抗患者肾脏组织中c-Jun和c-Fos的表达及意义。方法根据糖皮质激素治疗效果将45例原发性肾病综合征患者分为3个组:激素敏感组、激素抵抗组、复发后抵抗组,每组15例。用免疫组织化学方法检测45例原发性肾病综合征患者肾组织中c-Jun和c-Fos的表达,并用计算机图像分析系统对结果进行分析。结果复发后抵抗组和激素抵抗组肾组织中c-Jun和c-Fos含量明显高于激素敏感组(P<0.05);复发后抵抗组肾组织中c-Jun和c-Fos与激素抵抗组之间差异无统计学意义(P>0.05)。结论肾组织中c-Jun和c-Fos的升高可能与原发性肾病综合征激素抵抗有关;检测肾组织中c-Jun和c-Fos表达变化有助于判断预后和调整治疗方案。

Objective To investigate the role of c-Jun and c-Fos in the occurrence of steroid resistant nephrotic syndrome（NS）. Methods The 45 patients were divided into 3 groups （steroid sensitive group, steroid resistant group and reoccurrent steroid resistant group） according to the response to the treatment with corticosteroids. The expression of c-Jun and c Fos in renal tissues were tested by immunohistochemistry technique in 45 NS patients before treatment with corticosteroids. Results The expression of c-Jun and c Fos in renal tissues increased markedly in the patients with steroid resistant nephrotic syndrome and reoccurrent steroid resistant nephrotic syndrome groups compared with the steroid sensitive group. There was no significant difference of expression of e- Jun and c-Fos in renal tissues between steroid resistant group and recurrent steroid resistant group. The level of c Jun and e-Fos of recurrent group was significant higher than that of before the recurrent. Conclusion The increase of c-inn arid c Fos level might relate with the steroid resistant in nephrotic syndrome patients,although it is uncertain that change is cause or the result. But the analysis of serum c Jun and c Fos might be beneficial to predict the occurrence of steroid resistance in NS patients.