蕈样肉芽肿皮损细胞间粘附分子-1及白细胞功能相关抗原-1表达

Expression of intercellular adhesion molecule-1 and leukocyte function associated antigen-1 in skin lesion of mycosis fungoides

目的：为了探讨蕈样肉芽肿（MF）淋巴细胞亲表皮机制。方法：对9例MF皮损中细胞间粘附分子－1（ICAM－1）及白细胞功能相关抗原－1（LFA－1）的表达进行了检测。结果：ICAM－1和LFA－1表达与MF临床分期无关，角朊细胞ICAM－1表达强度与真皮内淋巴细胞LFA－1表达强度呈显著正相关（r's＝0．878，P＜0．005）。结论：提示MF的淋巴细胞亲表皮性与ICAM－1／LFA－1依赖性机制有关。

In order to study the mechanism of lymphocyte epidermotroism in mycosis fungoides (MF).Method We determined the expression of intercellular adhesion molecule-1 (ICAM-1) and leukocyte function associated antiogen-1 (LFA-1) in skin lesion of 9 cases of MF. Results The expression of ICAM-1 and LFA-1 was not correlated to the clinical stage of MF, however, there was significant correlation between ICAM-1expression in keratinocytes and LFA-1 expression in lymphocytes. Conelusion The lymphocyte epidermotropism is involved in ICAM-1/LFA-1 dependent mechanism.