紫杉类药物治疗卵巢癌

THE TREATMENT OF OVARIAN CANCER WITH PACLITAXELS

目的：阐述２种紫杉类药物紫杉醇和泰索帝的药理及临床疗效。方法：通过经典的临床试验方法治疗卵巢癌。结果：紫杉醇、泰索帝单药及联合用药均对卵巢癌有效，合用药物为顺铂、环磷酰胺。对铂类耐药的卵巢癌选用紫杉醇有较好疗效。紫杉醇剂量为１３５～２００ｍｇ／ｍ２，疗程３周。泰索帝剂量为７５～１００ｍｇ／ｍ２，均持续静滴３～２４ｈ，疗程３周。不良反应主要是骨髓抑制、过敏反应及胃肠道反应等。

OBJECTIVE:The pharmacological properties and clinical efficacy of paclitaxels were presented.METHODS:The classical method for clinical trial was adopted.RESULTS:Paclitaxel and docetaxel were effective in treatment of ovarian cancer in both regimens of single therapy and of combined therapy with cisplatin and cytoxan.Paclitaxel is more effective in treatment of ovarian cancer resistant to platinum.The dosage for paclitaxel is 135～200 mg/m2 iv drip 3～24 hours,and for docetaxel is 75～100 mg/m2 iv drip 1 hour.The main adverse reactions are bone marrow suppression,allergy and gastrointestinal response.CONCLUSION:Paclitaxel and docetaxel are effective agents for treatment of ovarian cancer.