匹维溴铵对小鼠功能性腹泻及便秘的治疗作用

Therapeutic effects of pinaverium bromide in functional constipation and diarrhea in mice

目的评价匹维溴铵对实验性便秘及腹泻小鼠的治疗作用．方法昆明小鼠３８只，随机分为腹泻组（ｎ＝１４），便秘组（ｎ＝１４）及正常对照组（ｎ＝１０）．采用复方苯乙哌啶制作小鼠便秘模型，番泻叶制作小鼠腹泻模型．便秘组及腹泻组动物分别给予匹维溴铵２００ｍｇ／ｋｇ·ｄ，正常对照组给予等体积生理盐水灌胃．观察各组ｄ０、ｄ１、ｄ３、ｄ５小鼠干粪点数、不排便只数、腹泻指数变化．ｄ５处死小鼠，取小鼠结肠做病理切片，观察结肠粘膜改变．结果匹维溴铵治疗结束时，腹泻治疗组小鼠的腹泻指数与正常对照组相比无差异（０００ｖｓ０００，Ｐ＞００５），与腹泻对照组相比明显降低（０００ｖｓ０７９±０１２，Ｐ＜００１），便秘治疗组小鼠的干粪点数与正常对照组相比无差异（１６４２±５２９ｖｓ１６５０±１８７，Ｐ＞００５），与便秘对照组相比明显增加（１６４２±５２９ｖｓ４８３±４２６，Ｐ＜００１）．结论我们采用非特异性的小鼠腹泻及便秘模型进行的研究结果表明，匹维溴铵对小鼠非特异性腹泻及便秘有明显的治疗作用．

IM To assess the therapeutic in effects experimental constipation and diarrhea in mice. METHODS Thirtyeight Kunming mice were randomly divided into three groups: diarrhea group, constipation group and control group. Constipation models were made by Diphenoxylatum and diarrhea models by Folium sennae. Constipation and diarrhia groups were treated by pinaverium at a dose of 200mg/kg body weight daily. Control group was fed with 09% NaCl. RESULTS In diarrhea group, the incidence rate of diarrhea was decreased after treatment (000±000). In control and constipation groups, the defecation numbers are increased markedly. CONCLUSION Pinaverium can relieve the symptoms of diarrhea and constipation in mouse models. .