参麦液对离体氧反常大鼠心脏作用实验研究

EFFECT OF SHEN-MAI SOLUTION ON ISOLATED RAT HEART OF OXYGEN PARADOX INJURY

目的：探讨参麦液对离体氧反常心脏的影响。方法：随机将ＳＤ大鼠分成４组，分别予以富氧、乏氧、异搏定和参麦液灌流，记录心肌收缩力与心电曲线，测量冠脉流量与心肌内丙二醛含量。结果：参麦液组灌注能有效恢复受损心肌收缩力（Ｐ＜００１）和丙二醛含量（Ｐ＜００５），不能降低心律失常发生率。

OBJECTIVE: To study effect of Shen-Mai solution on isolated rat heart of oxygen paradox injury. METHODS: SD rats were divided into four groups in random and were perfused by oxygen, oxygen lack, verapamil and Shen-Mai solution. Myocardial contractility, EKG, coronary blood flow and myocardial malonic aldehyde were recorded. RESULTS: Shen-Mai solution could effectively improve myocardial contractility of injured cardiac muscle ( P <0 01) and increase contents of malonic aldehyde ( P <0 05), but could not reduce incidence of arrhythmia. CONCLUSIONS: Attention should be paid to reperfused arrhythmia while use of Shen-Mai solution as positive inotropic medicine.