糖尿病血瘀证与血浆α-颗粒膜蛋白和内皮素关系的研究

A Study of the Diabetic Blood Stasis Syndrome and Its Implication with the Plasma Alpha Granule Membrance Protein and Endothelin

目的探讨Ⅱ型糖尿病血瘀证与血小板活化和血管内皮细胞之间的关系。方法采用酶联免疫吸附法以及放射免疫法，测定７４例Ⅱ型糖尿病患者血浆α－颗粒膜蛋白（ＧＭＰ－１４０）和内皮素（ＥＴ）的浓度，并与２０名健康者作对照比较。结果Ⅱ型糖尿病患者血浆中ＧＭＰ—１４０与ＥＴ的浓度明显增高（Ｐ＜０．０１，Ｐ＜０．００１）；糖尿病血瘀证这两项指标的变化比无血瘀证者更为明显（Ｐ＜０．０１，Ｐ＜０．００１）。结论Ⅱ型糖尿病患者血小板活化程度增强和内皮细胞功能受损。ＧＭＰ—１４０和ＥＴ与糖尿病血瘀证的发生有密切联系，这两项指标增高对判断血瘀证有一定的意义。

Recurring to the enzyme linked immune sorbent analysis and radioimmunoassay,determination has been made for the density of the plasma’s alpha granule membrance protein(GMP 140) and endothelin (ET) for 74 cases of the NIDDM patients and a study of their link to the blood stasis syndrome has been made.The results marked a significant increase of density of GMP 140 and ET in the plasma of the NIDDM patients showing that the NIDDM patients got their platelet activation increased and endothelial cell disfunctioned.Clinical examination also observed that the fluctuation of the two indicators determined in the diabetes mellitus associated with blood stasis syndrome is more significant than that in the diabetes mellitus not associated with blood stasis syndrome.It is indicated that GMP 140 & ET are closely linked to the occurrance of the diabetic blood stasis syndrome.The increase of the two indicators does make a point for judging blood stasis syndrome.It is also indicated that the NIDDM patients clinically not associated with blood stasis syndrdme began to show pathological and physiological alternations which are similar to those of the NIDDM patients associated with blood stasis syndrome.