紫杉醇脂质体与希罗达联合治疗老年晚期胃癌31例临床观察

目的观察紫杉醇脂质体与希罗达联合治疗对老年晚期胃癌近期疗效及毒副反应。方法希罗达2500mg·m^-2分早晚2次口服，连服14d。第1天给予紫杉醇脂质体135mg·m^-2静脉点滴，21d（或28d）为1个周期。结果3l例全部可评价疗效，CR1例，PR13例，SD11例，PD6例，总有效率（CR＋PR）45．1％，中位无进展生存期（5．1±0．5）个月。结论紫杉醇脂质体联合希罗达联合治疗对老年晚期胃癌疗效好，副作用小，老年患者耐受性好。

Objective To evaluate the effects and adverse reactions of paclitaxel liposome and xeloda in elderly patients with advanced gastric cancer. Methods Paclitaxel liposome was given 135mg·m^-2 on day 1, and xeloda was given 2500mg·m^-2 twice a day for 14 days. The chemotherapy was repeated every 3 or 4 weeks. Results The 31 patients were evaluable for response. CR 1 case, PR 13 cases, SD 11 cases, and PD 6 cases. The overall response rate was 45. 1%. The mean time to tumor progression was 5.1 ± 0. 5 months. Conclusion Paclitaxel liposome and xeloda is effective in the treatment of patients with advanced gastric cancer, the toxicity is acceptable and it may be an effective regimen.