儿童热性惊厥NSE与视频脑电图检测的临床研究

目的探讨血清NSE（神经元特异性烯醇化酶）和视频脑电图在热性惊厥儿童中的诊断价值。方法通过对40例单纯性热性惊厥患儿和30例复杂性热性惊厥患儿在发作以后的第1天和第7天用酶联免疫法（ELISA）对NSE进行检测。同时对所有患儿在发作第1天、第7天和1个月进行视频脑电图检查。结果在惊厥后24h和7d NSE水平差异有统计学意义（P〈0．01）；NSE浓度在单纯性惊厥和复杂性惊厥中差异亦有统计学意义（P〈0．01）。NSE恢复的越慢，脑电图的异常率越高。结论患儿NSE在发作以后24h内明显增高，尤其是复杂性惊厥患儿。视频脑电图的异常率和NSE浓度变化有相关。

Objective To discuss the diagnostic value of serum neuron specific enolase （NSE） and video EEG in febrile convulsion of children. Methods The serum NSE was measured by ELISA at 1 st and 7th day after seizure in 40 children with simple febrile convulsion and 30 with complex febrile convulsion. And video EEG examine were pertormed on 1 st ,7th and 30th day in all the patients. Results The differences were significant between NSE levels at 1 st and 7th day after convulsion （P 〈 0. 01 ）. NSE concentrations in patients with SFC and CFC were also different（ P 〈 0.01 ）. The more slowly NSE returned to normal, the higher the abnormal ratio of EGG was. Conclusion NSE increases in patients within 24 hours after seizure, especially in CFC patients. The abnormal ratio of video EEG was related to the change of NSE concentration.