1Casaburi R, Kukafka D, Cooper CB, et al. Improvement in exercise tolerance with the combination of tiotropium and pulmonary rehabili - tation in patients with COPD. Chest,2005,127 ( 3 ) : 809 - 817.
2Casaburi R, Mahler DA, Jones PW, et al. A Long - term evaluation of once - daily inhaled tiotropium in chronic obstructive pulmonary disease. EnrRespir J,2002,19 (2) :217 - 224.
5Niimi - Matsumoto H, Minakuchi M. Airway remodeling in cough variantasthma. Lancet,2005,356(9229) :564 -565.
6Levin DC, Little KS, Laughlin KR, et al. Addition of anticholinergic solution prolongs bronchodilator effect of beta 2 agonists in patients with chronic obstructive pulmonary disease. Am J Med, 1996,100 (1A) :40S -48S.
2Koum is T, Sam uel S. Tiotrop ium brom ide: a newlong - acting bronchodilator for the treatment of chronic obstructive pulmonary diease. Clin Ther, 2005,27 : 377 - 392.
3van Nood J A, Au mann J L, Janssens E, et al. Effects of tiotropium with arid without formoterol on airflow obstruction and resting hyperinflation in patients with COPD. Chest, 2006,129 : 507 - 517.
4van Nood J A, Au mann J L, Janssens E, et al. Comparison of tiotropium once daily, formoterol twice daily and both combined once daily in patients with COPD. Eur Respir J, 2005,26 : 214 - 222.
5Soler Cataluna JJ, Martinez MA, Sanchez PR, et al. Sever acute exacerbations and mortality in patients with chronic obstructive pulmonary disease. Throax, 2005,60: 925 - 931.
6Bestall JC,Paul EA,Garrod R,et al.Usefulness of the Medical Council (MRC) dyspnoea scale as a measure of disability in patients with chronic obstructive pulmonary disease[J].Thorax,1999,54(7):581-586.
7Spector WD,Katz S,Murphy JB,et al.The hierarchical relationship between activities of daily living and instrumental activities of daily living[J].J Chronic Dis,1987,40(6):481-489.
8ATS committee on proficiency standards for clinical pulmonary function laboratories.ATS statement:guidelines for the six-minute walk test[J].Am J Respir Crit Care Med,2002,166(1):111-117.
9Tashkin DP, Celli B, Senn S, et al. A 4-year trial of tiotropium in chronic obstructive pulmonary disease[J]. N Engl J Med, 2008,359 ( 15 ) : 1543-1554.
10Sin DD, Man SF, Marciniuk DD, et al. The effects of fluticasone with or without salmeterol on systemic biomarkers of inflammation in chronic obstructive pulmonary disease[J]. Am J Respir Crit Care Med,2008,177 ( 11 ): 1207- 1214.