N-乙酰化酶多态性与胃癌关系的研究

STUDY ON THE ASSOCIATION OF THE N-ACETYLTRANSFERASE POLYMORPLISM WITH GASTRIC CANCER

代谢酶多态性决定着机体对外源化学物的易感性和耐受性，也是肿瘤发生的遗传易感影响因素之一。本文报道了胃癌病人中Ｎ－乙酰化酶多态性的调研。３４例胃癌病人中１３例为慢型（３８２４％）；对照组１０７人中２０人为慢型（１８６９％）。基因频率分别０６１８３和０４３２３，两者之间有显著差异（Ｐ＝０．０２２）。从中推算出乙酰化酶慢型者患胃癌的相对危险度为２６９（１１６～６．２７），说明乙酰化酰慢型作为肿瘤遗传易感因素，在胃癌发病中的作用不应忽视。

Polymorphism of metabalic enzyme is one of the factors relevant to the susceptibility to environmental chemicals and heredicary predispositional to carcinogenesis. The polymorphism of N-acetyltransferase among gastric cancers is investigated and reported. It was found that 13 among 34 GC patients (38.24%) were slow type of N-AT versus the referring figure 20/107 (18.69%) in the controls. Their gene frequencies were calculated as 0.6183 and 0.4323 respectively, the difference was statistically significant (P=0.022). The OR of GC for slow N-AT was 2.69 (1.16-6.27), suggesting that slow N-AT should be considered as one possible aetiological factor of GC.