脑梗死中医证型与血脂关系的临床研究

Clinical study on relationship between TCM syndrome types and blood iipids in patients with cerebral infraction

目的观察脑梗死中医证型与血脂指标之间的关系，为其证型辨证提供客观依据。方法将120例患者经辨证分为风痰瘀阻组（40例），痰热腑实组（40例），气虚血瘀组（40例），观察患者血脂的各项指标。结果TG、TC、LP（a）水平在风痰瘀阻组、气虚血瘀组和痰热腑实组呈现从高到低，且组间比较差异有统计学意义（P〈0．05）；HDL—C、LDL—C水平在风痰瘀阻与气虚血瘀组比较差异无统计学意义（p〉0．05）；痰热腑实组的HDL-C水平高于其它两组，且差异有统计学意义（．P〈0．05）；气虚血瘀组的LDL—C高于其它两组，且差异有统计学意义（P〈0．05）；ApoA、ApoB水平在各组间比较差异无统计学意义（P〉0．05）；ApoE水平在风痰瘀阻组、气虚血瘀组和痰热腑实组呈现从高到低，且组间比较差异有统计学意义（P〈0．05）。结论可以运用血脂指标对脑梗死的中医辨证分型进行判别分类；“痰”“瘀”是中风实邪的物质基础。

Objective To observe the relationship between TCM syndrome types and blood lipids in patients with cerebral infraction in an attempt to provide an objective basis for distinguishing TCM syndrome types. Methods 120 patients were equally divided into three groups： wind-phlegmandbloodstasis （WPBS） group, phlegm-heat and intestines bungingup （PHIB） group, and qi deficiency and blood stasis （QDBS） group. Blood lipid levels were observed in these patients. Results TG, TC and LP （a） levels were significantly higher in WPBS group than those in QDBS group, and even higher than those in PHIB group （P〈0.05）. There was no significant difference in HDL-C and LDL-C between WPBS and QDBS groups （P 〉 0.05）. HDL-C and LDL-C levels were significantly higher in PHIB group than those in the other two groups （both P 〈 0.05）. There was no significant difference in ApoA and ApoB levels between the three groups （P 〉 0.05）. ApoE level was higher in PHIB group than that in QDBS group, and even higher than that in WPBS group （P 〈 0.05）. Conclusions Blood Lipids could be used to distinguish TCM syndrome types in patients with cerebral infraction. ＂Phlegm＂ and ＂blood stasis＂ may offer an objective basis for stroke-provoking evils.