中西医结合治疗新生儿硬肿症

Sclerema neonatorum treated by TCM WM

目的：观察复方丹参注射液配以活血化瘀中药油膏局部包敷治疗新生儿硬肿症的疗效。方法：将１５６例新生儿硬肿症患儿随机分为２组。治疗组９６例除一般治疗外，给予复方丹参注射液静滴并外用中药油膏硬肿区局部包敷。对照组６０例单纯用西药补液、纠酸、抗凝、抗炎、营养支持及对症处理。结果：治疗组症状好转时间为（４．２５±１．７５）日、症状恢复正常时间为（５．５０±２．２５）日、体温恢复正常时间为（１．０５±０．８５）日和硬肿消退时间为（４．９５±２．５５）日，均优于对照组〔分别为（５．２０±１．８５）日、（６．１０±２．１４）日、（１．３０±０．９０）日和（６．３６±２．３０）日〕（Ｐ均＜０．０１）。治疗组显效７５例，有效１５例，无效６例，总有效率９３．７５％；对照组显效１２例，有效３０例，无效１８例，总有效率７０．００％，治疗组疗效优于对照组（χ２＝１５．９９，Ｐ＜０．０１）。结论：复方丹参注射液配以活血化瘀中药油膏局部包敷治疗新生儿硬肿症疗效明显优于单纯西医治疗。

Objective:To observe the therapeutic efficacy of composite salvia miltiorrhiza injection combined use of Huoxue Huayu ointment for local package on sclerema neonatorum.Methods:One hundred and fiftysix cases of sclerema neonatorum were divided into 2 groups:treatment group (n=96) was treated with composite salvia miltiorrhiza injection (intravenous drip) and traditional Chinese ointment (local package) on the basis of general therapy;control group (n=60) was treated with infusion,correcting acidosis,anticoagulation,antiinflammation,nutrition and support therapy.Results:The time of symptom improvement was (425±175) days,time of symptom return to normal was (550±225)days,time of temperature return to normal was (105±085) days and time of subsidencing sclerema was (495±225) days,they were superior to control group,which was (520±185) days,(610±214) days,(130±090) days and (636±230) days respectively (all P<001).On the other hand,75 cases were obviously improved,15 cases were improved,6 cases were no improved,the total effective rate was 9375%;in control group,they were 12 cases,30 cases,18 cases and 7000% respectively.So the effectiveness of treatment group was superior to control group (χ2=1599,P<001).Conclusions:There have an obvious therapeutic effect of composite salvia miltiorrhiza injection combined use of Huoxue Huayu ointment local package on sclerema neonatorum,it is superior to western medicine therapy alone.