HBV前C区1896位点变异与HBV感染者肝功能损害程度的关系

STUDY OF THE RELATIONSHIP BETWEEN THE HBV PRECORE (NT1896) MUTANT AND LIVER FUNETION

了解ＨＢＶ前Ｃ区１８９６位点变异与乙型肝炎病毒感染者肝功能损害程度的关系。方法：用ＰＣＲ技术，通过改变引物３’端的方法，检测ＨＢＶ感染者的前Ｃ区第１８９６位点变异株。结果：１０５例ＨＥＶ感染者中的ＨＢＶ前Ｃ区１８９６位点变异株总检出率为５６．２％；男性与女性患者的检出率分别为５７．０％与５００％；≤３０岁组，３１－５９岁组，≥６０岁年龄组的检率分别为６０．０％，５６．６％，２８．６％；无黄疸组，轻～中度黄疸组，重度黄疸组的检出率分别为５３．２％，６５．１％，４０．０％；在ＨＢＶ携带者、慢性肝炎（包括轻、中、重庆），重症肝炎及肝硬化患者中的检出率分别为６０．０％，５７．４％，３３．３％，７０．０％。结论：ＨＢＶ前Ｃ区１８９６位点突变株广泛存在于ＨＢＶ感染者中，而且其检出率与患者性别、年龄、ＨＢＶ感染时间长短及肝功能损害程度并无明显联系。

In order to study the relationship between the HBV precore(nt1896) mutant and liver function,the precore HBV(nt1896)mutant was detected in 105 cases of hepatitis B using PCR. The total positive rate precore HBV (nt 1896) mutant was 56.2%(59/105) in pa- tients with Hepatitis B. HBV precore (nt 1896) mutant was detected in 53 of 93 male patients (57.0% ) , and in 6 of 12 female patients (50.O%). There were no significant differences in the positive rates among the different age groups. The patients with ages less than 31 years had a 60.6% positive rate ,31 to 59 years had a 56.6% positive rate, and those 60 years or older had a 28.6% positive rate for the HBV precore (nt 1896) mutant. The positive rate for patients with no jaundice, mild jaundice, and grave jaundice were 53 . 2% , 65 . 1% and 40.O%, respectively . The HBV precore (nt 1896) mutant was also detected in patients with HBV carrier (60.O%;3/5), chronic hepatitis (57.4% ;39/68), severe hepatitis (33.3% ;3/9) and cirrhosis (70.O% ;14/20). The HBV precore (nt 1896) mutant was de- tected in major patients with hepatitis B, and had no relationship to the patients'sex, age, duration of the disease, or the severity of under- lying liver diseases.