肺结核患者血清IL-8水平的研究初探

STUDY OF THE SERUM IL-8 LEVELS IN PATIENTS WITH ACTIVE PULMONARY TUBERCULOSIS

ＩＬ－８是近来研究甚多的炎症性细胞因子之一，在结核菌感染中亦受到人们的重视。该文研究新近诊断的活动性肺结核、慢性非活动性肺结核反正常对照组血清ＩＬ－８水平。结果提示活动性肺结核患者血清ＩＬ－８水平显著高于慢性非活动性肺结核及正常对照组，而后两者血清ＩＬ－８水平无显著性差异。由此推测ＩＬ－８在结核菌感染早期的免疫反应中起着重要作用，可作为临床上判断肺结核活动性的指标之一。

Interleukin-8 (IL-8) is one of the most widely studies cytokines in recent years and is also important in the infection of tubercle bacillus. The serum n. IL - 8 level of newly diagnosed patients with acitive pulmonary uberculosis and chronic non-active pulmonary tuberculo- sis were studied and compared with normal subjects. The results suggest that the serum IL - 8 levels in patients with active tuberculosis are significantly higher than those of patients with chronic non-active tuberculosis and those of normal controls .No significant differences were observed between patients with chronic non-active tuberculosis and the control group. It. is speculated that IL - 8 serves as an important cy- tokine in the irnmunological reaction to the infection of tubercle bacillus, and IL - 8 may indicate the level of tuberculosis activity.