磷酸肌酸钠对重度窒息新生儿血清肌酸激酶同工酶和心肌肌钙蛋白Ⅰ的影响

Effect of sodium phosphocreatine on CK-MB and cTnI in severe asphyxia neonates

目的观察磷酸肌酸钠对重度窒息新生儿血清肌酸磷酸激酶同工酶(CK-MB)和心肌肌钙蛋白I(cTnI)的影响。方法入选重度窒息新生儿60例,按照入院顺序随机分为治疗组和对照组,每组30例患儿,均给予常规对症支持治疗,治疗组在常规对症支持治疗基础上加用磷酸肌酸钠,1 g/d,静脉滴注,6～7 d为一疗程。比较治疗前后两组患儿血清CK-MB和cTnI水平的变化。结果治疗前两组患儿血清CK-MB和cTnI水平均高于正常水平,但两组间差异无统计学意义[治疗组分别为(68.7±18.7)U/L、(2.73±0.22)μg/L;对照组分别为(68.8±19.3)U/L、(2.85±0.20)μg/L](P>0.05)。治疗3 d后,治疗组血清CK-MB和cTnI水平显著下降[(24.4±3.1)U/L、(0.36±0.03)μg/L](P<0.01),接近正常水平;而对照组则在7 d后恢复至正常水平[(27.8±2.5)U/L、(0.77±0.03)μg/L]。结论磷酸肌酸钠能够快速有效地降低重度窒息新生儿血清CK-MB和cTnI的水平。

Objective To observe the effect of sodium phosphocreatine on serum levels of CK-MB and cTnI in severe asphyxia neonates. Methods Sixty severe asphyxia neonates were enrolled and randomly assigned to therapy group （n = 30） or control group （ n = 30 ）. All patients received conventional therapy, therapy group was added sodium phosphocreatine infusion lg/d for 6-7 days. The serum CK-MB and cTnI were compared between the 2 groups before and after treatment. Results There was no significant difference in the levels of CK-MB and cTnI between the 2 groups [ therapy group ： （68.7 ± 18.7） U/L, （2. 73 ±0. 22） μg/L;control group： （68. 8 ± 19. 3 ） U/L, （2. 85 ±0. 20） μg/L] （P 〉 0.05）. CK-MB and cTnI levels in therapy group were significantly decreased 3 days after treatment [ （24. 4± 3.1 ） U/L, （0. 36 ±0. 03） μg/L] （P 〈 0. 01 ） and returned to normal range, while those in control group returned to normal levels after 7 days[ （27. 8 ±2. 5） U/L, （0. 77 ± 0. 03 ） μg/L]. Conclusions Sodium phosphocreatine treatment decreases the serum level of CK-MB and eTnI effectively in severe asphyxia neonates.