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抑癌基因PTEN与心血管疾病研究进展 被引量：1

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摘要 1997年Li等在浸润性乳腺癌的两个移植瘤中发现了10q23染色体特定区域的杂合子丢失，并通过外显子俘获分析法分离出一种新的基因，对其开放性阅读框序列分析，
作者 张冀东 崔炜
机构地区 河北医科大学第二医院心内科
出处 《中国心血管杂志》 2009年第6期486-488,共3页 Chinese Journal of Cardiovascular Medicine
关键词 抑癌基因PTEN 心血管疾病 浸润性乳腺癌 杂合子丢失 特定区域 序列分析 染色体 移植瘤
分类号 R54 [医药卫生—心血管疾病]
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参考文献21

  • 1Li J, Yen C, Liaw D, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science, 1997, 275:1943-1947.
  • 2Shim JH, Kim YS, Bahk YY. Proteome profile changes that are differentially regulated by lipid and protein phosphatase activities of tumor suppressor PTEN in PTEN-expressing U-87 MG human glioblastoma cells. Proteomics, 2006,6 : 81-93.
  • 3Valiente M, Andres-Pons A, Gomar B, et al. Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases. J Biot Chem, 2005, 280:28936-28943.
  • 4Subramanian KK,Jia Y, Zhn D, et al. Tumor suppressor PTEN is a physiologic suppressor of chemoattraetant-mccliated neutrophil functions. Blood, 2007, 109:40284037.
  • 5Hartmann W, Digon-Sontgerath B, Koch A, et al. Phosphatidylinositol 3'-kinase/AKT signaling is activated in medulloblastoma cell proliferation and is associated with reduced expression of PTEN. Clin Cancer Res, 2006, 12:3019-3027.
  • 6Hamada K,Sasaki T, Koni PA, et al. The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev, 2005, 19:2054-2065.
  • 7Shen YH, Zhang L, Gan Y, et al. Up-regulation of PTEN (phosphatase and tensin homolog deleted on chromosome ten ) mediates p38 MAPK stress signal-induced inhibition of insulin signaling. A cross-talk between stress signaling and insulin signaling in resistin-treated human endothelial cells. J Biol Chem, 2006, 281:7727-7736.
  • 8Tang Y, Eng C. PTEN autoregulates its expression by stabilization of p53 in a phosphatase-independent manner. Cancer Res, 2006, 66:736-742.
  • 9Vasudevan KM, Gurumurthy S, Rangnekar VM. Suppression of PTEN expression by NF-kappa B prevents apoptosis. Mol Cell Biol, 2004, 24: 1007-1021.
  • 10Kaper F, Dornhoefer N, Giaccia AJ. Mutations in the PI3K/ PTEN/TSC2 pathway contribute to mammalian target of rapamycin activity and increased translation under hypoxic conditions. Cancer Res, 2006, 66: 1561-1569.

二级参考文献36

  • 1师永红,王玉湘,由江峰,衡万杰,钟镐镐,方伟岗.PI-3K和MEK1/ERK信号通路在碱性纤维母细胞生成因子诱导乳腺癌细胞低氧诱导因子活化中的作用及机制[J].中华医学杂志,2004,84(22):1899-1903. 被引量：12
  • 2陈庆永,王春友,吴河水,陈道达.外源性PTEN基因诱导人乳腺癌MDA468细胞凋亡[J].中华医学杂志,2005,85(1):33-36. 被引量：12
  • 3于林君,祝善俊,周裔忠,田颖,王江,祝之明.携带野生型PTEN基因的腺病毒载体的构建[J].免疫学杂志,2005,21(3):240-243. 被引量：6
  • 4Myers MP, Stolarov JP, Eng C, et al. P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc Natl Acad Sci U S A,1997, 94:9052-9057.
  • 5Simpson L, Parsons R. PTEN: life as a tumor suppressor. Exp Cell Res, 2001,264:29-41.
  • 6Schwartzbauer G,Robbins J. The tumor suppressor gene PTEN can regulate cardiac hypertrophy and survival. J Biol Chem, 2001,276:35786-35793.
  • 7Yamazaki T, Komuro I, Shiojima I, et al.The molecular mechanism of cardiac hypertrophy and failure. Ann NY Acad Set, 1999, 874: 39-48.
  • 8Molkentin JD. Calcineurin and beyond: cardiac hypertrophic signaling.Circ Res, 2000, 87: 731-738.
  • 9Myers M P, Stoarov JP, Eng C, et al. PTEN the tumor suppressor from human chromosoe 10q23, is a dual-specificity phosphaase. Proc Natl Acad Sci, 1997, 94: 9052-9057.
  • 10Maehama T, Dixon J E. PTEN: A tumor suppressor that functions as a phospholipid phosphatase. Trens cell Biol, 1999, 9: 125-128.

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中国心血管杂志
2009年 第6期

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