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1Kirsten Kortram,Bert van Ramshorst,Thomas L Bollen,Marc GH Besselink,Dirk J Gouma,Tom Karsten,Philip M Kruyt,Grard AP Nieuwenhuijzen,Johannes C Kelder,Ellen Tromp,Djamila Boerma.Acute cholecystitis in high risk surgical patients: percutaneous cholecystostomy versus laparoscopic cholecystectomy (CHOCOLATE trial): Study protocol for a randomized controlled trial. Trials . 2012