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原癌基因c-maf在多发性骨髓瘤中的研究进展

Advances on the c-maf Proto-oncogene in Multiple Myeloma
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摘要 人类多发性骨髓瘤是一种难以治愈的B淋巴细胞恶性分化的疾病,其细胞遗传学特征表现在染色体异常.原癌基因c-maf在多发性骨髓瘤细胞中高水平表达,其编码的c-Maf蛋白作为转录因子,通过作用于5个下游靶基因CCND2、ITGB7、CCR1、SPP1和ARK5,与细胞周期调控、肿瘤细胞的黏附性、肿瘤侵袭和转移、血管发生等方面有关.原癌基因c-maf和/或c-Maf蛋白有可能作为治疗多发性骨髓瘤的新靶点. Human multiple myeloma is an incurable disease of malignant differentiated B lymphocytes. Its cytogenetics is characterised by chromosomal abnormalities. The c-maf proto-oncogene is expressed at high level in multiple myeloma cells. As a transcription factor, the c-Mar protein through the five downstream target genes： CCND2, 1TGB7, CCR1, SPP1 and ARKS, is involved in cell cycle regulation, adhesion of tumor cells, tumor invasion and metastasis, angiogenesis and other aspects. The c-mar proto-oncogene and/ or c-Maf protein may be a novel therapeutic target in multiple myeloma.
作者 屈强 胡维新
机构地区 中南大学生物科学与技术学院分子生物学研究中心
出处 《生命科学研究》 CAS CSCD 2009年第6期554-557,共4页 Life Science Research
基金 国家自然科学基金资助项目(30770906)
关键词 原癌基因 C-MAF c-Maf蛋白 多发性骨髓瘤 proto-oncogene c-maf c-Maf protein multiple myeloma
分类号 Q71 [生物学—分子生物学]
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生命科学研究
2009年 第6期

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