法莫替丁联合羟氨苄青霉素、替硝唑根除幽门螺杆菌的疗效观察

The Observation of Effecacy of Famotidine in Combination with Amoxycillin and Tinidazole on Eradication of helicobacter pylori

目的：评价法莫替丁（高舒达）、羟氨苄青霉素、替硝唑三联疗法对幽门螺杆菌（Ｈｐ）相关性消化性溃疡的疗效。方法：将８５例Ｈｐ阳性的十二指肠和／或胃溃疡患者随机分为２组：①法莫替丁组，４２例，每次口服法莫替丁２０ｍｇ、羟氨苄青霉素１０００ｍｇ、替硝唑５００ｍｇ，均每日２次，；②兰索拉唑（达克普隆）组４３例，每次口服兰索拉唑３０ｍｇ、羟氨苄青霉素１０００ｍｇ、替硝唑５００ｍｇ，也均为每日２次，进行对照观察。均２周为１疗程，疗程结束达４周时复查Ｈｐ。结果：兰索拉唑组有３例因过敏性皮疹终止治疗，余下４０例用于统计学分析。法莫替丁组和兰索拉唑组Ｈｐ根除率分别为８８．１％和９０．０％；十二指肠溃疡和／或胃溃疡的愈合率分别为９０．５％和９２．５％。结论：法莫替丁组的Ｈｐ根除率和溃疡愈合率与兰索拉唑组相比较，两组间的差异无显著性（Ｐ＞０．０５）。表明两种三联疗法对根除Ｈｐ和治疗消化性溃疡均有良好效果，均是可供选择的治疗方案。但前者有副作用较少。

Objective:To evaluate the efficacy of Famotidine(Gaster) in combination with Amoxycillin and Tinidazole on Hp positive peptic ulcer,this study was developed.Methods:Eighty five patients with Hp positive duodenal and/or gastric ulcer were randomly assigned to two groups:①Famotidine(Gaster) group,42 cases,took Famotidine 20mg,Amoxycillin 1000mg and Tinidazole 500mg,all twice perday.A course of treatment takes 2 weeks.②Lansoprazole(Takeperon) group,43 cases,took Lansoprazole 30mg,Amoxycillin 1000mg,and Tinidazole 500mg,all twice per day too to be observed comperatively.Hp infecfions were reexamined at the end of the fourth week after the course of treatment.Result:All cases of Lansoprazole group were analysed with statistics except for the three cases with allergic tetters.The rate of Hp eradication for Famotidine and Lansoprazole group were 88.1 and 90.0 percent respectively,and the healing rate of peptic ulcer for them were 90.5 and 92.5 percent respectively. Conclusion: There were no significant difference between two groups(P>005) in the Hp eradication rate and the ulcer healing rate.The results show that the two triple therapies are quite effective to eradicate Hp and treat peptic ulcer,while the former is cheaper and has less side effects.