乳腺疾病血清CA15-3测定及其临床意义

CLINICAL SIGNIFICANCES OF SERUM CA153 DETECTIONS IN BREAST DISEASES

目的：研究ＣＡ１５－３对乳腺疾病诊断及治疗的临床意义。方法：术前术后、化疗前、后分别抽取周围静脉血，酶联免疫吸附法（ＥＬＩＳＡ）测定ＣＡ１５－３水平。结果：乳腺癌ＣＡ１５－３阳性率为３６．８％，Ⅰ、Ⅱ、Ⅲ和Ⅳ期病变术前阳性率分别为１１．１％、２６．１％、４６．１％、１００％，复发和有远处转移病人阳性率为７５％，良性病变ＣＡ１５－３阳性率为１６．３％。ＣＡ１５－３阳性乳腺癌病人手术后或化疗后短期内ＣＡ１５－３水平即有不同程度下降。结论：ＣＡ１５－３是监测乳腺癌术后早期复发和疗效判断的一项有效指标。

Objective:To investigate the clinical significances of Serum CA153 levels in diagnosis and treatment of breast diseases.Methods:Peripheral blood serum samples were collected pre and postoperatively or before and after chemotherapy.CA153 levels were determined by enzyme linked immunosorbent assay (ELISA).Resu lts:In breast cancer patients the positive rate of CA153 was 3684%.In stage Ⅰ、Ⅱ、Ⅲ and Ⅳ patients the preoperative CA153 positive rate was 111%、261%、461% and 100% respectively.In patients with recurrence or distant metastasis the positive rate was 75%. In patients with benign breast diseases the CA153 positive rate was 163%. CA153 positive breast cancer patients experienced somewhat CA153 level decline after operation or chemotherapy.Within the short duration (2～4 weeks),the differences were not statistically significant.Conclusion:CA153 level determination is an effective index for monitoring early postoperative recurrence and therapeutic effect in breast cancer.