三种中期妊娠引产方法的探讨

Three methods of induction of labor in the midtrimester pregnancy

目的:探讨米非司酮配伍米索前列醇引产、依沙丫啶配伍米索前列醇引产及依沙丫啶羊膜腔内注射引产的临床效果。方法:将自愿终止妊娠的中期妊娠妇女138例随机分为A、B、C三组,A组46例,使用米非司酮配伍米索前列醇引产,B组46例,使用依沙丫啶配伍米索前列醇引产,C组46例,使用依沙丫啶羊膜腔内注射引产。比较三组引产的效果及不良反应。结果:三组用药至规律宫缩时间、总产程及产时产后2h内出血量比较,A、B两组均优于C组,差异有统计学意义(P<0.05);三组引产成功率、药物不良反应及胎盘、胎膜残留比较,差异无统计学意义(P>0.05)。结论:药物引产时间短,效果优于依沙丫啶注射引产,是一种方便、安全、快速、有效的引产方法。

Objective To investigate the clinical effects of mefepristone with misoprostol,intra - amniotic injection of ethacridine with misoprostol, and intra- amniotie injection of ethacrldiue in term/nation of midtrimestcr pregnancy. Method Total 138 pregnant women who required induction of labor were randomly divided into three groups as group A （mefepristone with misoprostol） ,group B （intra -amniotic injection of ethaeridine with misoprostol）, and group C （ intra - amniotic injection of ethacridine）. Results In the time periods of regular uterine contractions after different administrations, total stage of labor, bleeding during labor and two hours labor,group C showed significant difference compared with group A and group B, respectively （P 〈 0.05 ）. The success ratio of induction of labor, the associated side effects and residual of placenta and fetal membranes showed no difference among the three groups. Conclusion The medicine induces labor surpasses the ethacridine induces labor, with shorter time, and is a convenient, safe, fast, and effective method in the termination of midtrimester pregnancy.