血清瘦素水平与冠状动脉狭窄程度的相关性研究

Relationship between the level of serum leptin and the degree of coronary artery stenosis

目的:探讨血清瘦素水平与冠状动脉狭窄程度的相关性及其临床意义。方法:68例冠状动脉性心脏病(简称冠心病)患者按冠状动脉狭窄程度分级标准分为轻度狭窄组、中度狭窄组和重度狭窄组。应用放射免疫分析法检测三组冠心病患者及正常对照组血清瘦素水平。结果:血清瘦素水平与冠状动脉病变程度呈正相关(r=0.604,P<0.01)。结论:血清瘦素可成为判定冠状动脉狭窄程度的实验室诊断指标。

Objective To explore the relativity and clinical significance between leptin level and the degree of coronary artery stenosis. Method According to the evidence of coronary artery stenosis, the patients were classified into mild, middle and severe coronary artery stenosis groups by CAG. Radioimmunoassay was applied to determine the concentration of serum leptin in patients with CHD and referents. Results Serum leptin levels were positively associated with the degree of coronary artery stenosis （ r = 0. 604, P 〈 0.01 ）. Conclusion - Serum leptin level is positively associated with the degree of coronary artery stenosis. The results suggest that leptin can as the test reference of degree of coronary artery stenosis.