6-氯咪唑并[1,2-b]哒嗪的合成

Synthesis of 6-Chloroimidazo[1,2-b] pyridazine

以水合肼和马来酸酐为原料,经缩合、氯化、氨解和关环4步反应合成头孢唑兰的中间体6-氯咪唑并[1,2-b]哒嗪,总收率为65.5%。探讨了影响反应的主要因素,并通过1HNMR对产物结构进行了表征。

1,7-Bis（3-indolyl）-1,6-heptadiene-3,5-dione was synthesized by the condensation of complex formed by boron oxide and acethylacetone with indole-3-carboxaldehyde,and some side reactions that brought by active methylene group were avoided effectively.According to the single factor experiment and orthogonal experiment,the optimum conditions were obtained as follows： reaction time was 18 h;the molar ratio of indole-3-carboxaldehyde to complex was 4∶1;the volume of n-BuNH2 was 0.50 mL;the temperature of water tank was 75℃.Under above conditions,the yield could reach 52.4%.