多西他赛联合草酸铂及亚叶酸钙,5-氟脲嘧啶治疗晚期胃癌

Docetaxel Combined with Oxaplatin and Calcium Folinate,5-Fluorouracil in the Treatment of the Advanced Gastric Carcinoma

目的探讨多西他赛联合草酸铂及亚叶酸钙,5-氟脲嘧啶治疗晚期胃癌的疗效及毒副反应。方法多西他赛75 mg/m^2,d1、8,静脉滴注,草酸铂130 mg/m^2,d1,亚叶酸钙200 mg静脉滴注2 h后5-氟脲嘧啶500 mg/m2,持续静脉输注22 h,d1-5,21 d为1周期,所有患者均接受至少2个周期的治疗。结果全组CR 1例,PR 26例,总有效率48.2%,中位肿瘤进展时间（TTP）为6.3个月。其中初治38例,CR 0例,PR 19例,总有效率50.0%,中位TTP为6.9个月;复治18例,CR 1例,PR 7例,总有效率44.4%,中位TTP为6.1个月。主要毒副反应为骨髓抑制、恶心呕吐和脱发。结论多西他赛联合草酸铂,亚叶酸钙及5-氟脲嘧啶治疗晚期胃癌疗效肯定,特别对初治患者,毒副反应较轻,患者均能耐受,值得临床进一步扩大研究。

Objective To study the short-term efficacy ad toxicities of docetaxel combined with oxaliplatin and 5-fluorouracil in the treatment of advanced gastric carcinoma. Methods 56 patients with advanced gastric carcinoma were treated with doeetaxel（75 mg/m^2 ,d1,8 ） , oxaliplatin（ 130 mg/m^2 ,d1 ） and 5-fluorouraeil（500 mg/m^2 , d 1-5 ） , The chemotherapy was repeated every 21 days . All the patients were cured over two cycles treatments. Results There were l CR and 26 PR in all the cases ,the overall response rate was 48.2% ,the median TTP is 6.3 months. Among the primary treatment 38 patients,there was 0 CR and 19 PR, the overall response rate was 50.0% , the median TTP was 6.9 months. Among the retreated 18 patients,there was 1 CR and 7 PR, the overall response rate was 44.4% , the median TTP was 6.1 months. Major toxicities were bone marrow depression, nausea, vomitting and alopecia. Conclusion Docetaxel combined with oxaliplatin and 5-fluorouraeil in the treatment of advanced gastric carcinoma is effective. Especially for the primary treatment patients,the toxicities can be tolerant. It is worth expanding in the clinical work.