血清葡萄糖-6-磷酸异构酶在类风湿关节炎诊断中的意义

Study of serum glucose-6-phosphate isomerase in the diagnosis of rheumatoid arthritis

目的：探讨葡萄糖-6-磷酸异构酶（GPI）在类风湿关节炎（RA）诊断及与其他自身免疫性疾病鉴别诊断中的价值，并对GPI在RA中的致病机理进行初步分析。方法：检测RA组、健康对照组和其他自身免疫性疾病对照组血清的GPI、类风湿因子（RF）。结果：RA组的GPI浓度值和阳性率都显著高于其他自身免疫疾病对照组和健康对照组（P〈0．00I），且RA活动组GPI浓度值和阳性率显著高于RA非活动组（P〈0．001）。结论：GPI在RA中的检测意义要大于其他身免疫性疾病，且它的升高程度与关节炎的活动性有关，GPI和RF联合检测对RA的鉴别诊断具有较高价值；GPI可通过替代途径激活补体系统，损伤关节表面，导致RA的发生。

Objective To explore the differential diagnostic value of glucose-6-phosphate Isomerase（GPI） in rheumatoidarthritis（RA）.MethodsThe level of serum GPI,RF in the patients with RA, normalcontrols and other autoimmune diseases were assessed. And then all the results wereanalysed. ResultsThe concentration and positive rate of GPI in RA group were significantly higher than those in dis-ease control and normal control groups（P〈0.001）.And, the concentration and positive rate of GPI inRA activity group were sificantly higher than those in RA nonactivi group（P〈0.001）.Conclusion GPI is not specific diagnostic test for RA, but combining detec-tion of GPI and RF has much differential diagnostic value than each one of GPI or RF.GPI can activatethe complement system through the alternative pathway, and then injure joint surface, finally lead toRA.