1,4,7,10-N,N,N,N-四(2-(4-(2-乙酰硫基乙氧基)苯氧基)乙基)-1,4,7,10-四氮杂环十二烷的合成研究

Synthesis of 1,4,7,10-N,N,N,N-Tetra-(2-(4-(2-acetylthioethoxy)phenoxy)-ethyl)-1,4,7,10-tetraazacyclododecane

以对苄氧基苯酚为原料,经3步反应合成不对称的对苯二酚烷氧基化合物,并以此为原料,合成乙酰硫基修饰的cyclen四取代氢醌醚链化合物。该路线不仅反应条件温和,操作易行,且收率高,克服了文献报道的合成路线重复性差、收率低的缺点。关键中间体及目标化合物经1HNMR、13CNMR、MS、IR和元素分析表征。

Titled compound was conveniently synthesized from asymmetric hydroquinone alkoxy compound which was prepared from 4-（benzyloxy）phenol after three-step reaction.Compared to reported methods in literatures,this one was more readily performed with much better yields under mild conditions.The key intermediates and the target compound were characterized by 1H NMR,13 C NMR,MS,IR and elemental analysis.