摘要
目的评价成人接种不同种类10μg乙肝疫苗后的免疫效果。方法选择寿光市年龄在20岁以上的乙肝表面抗原(HBsAg)、乙肝表面抗体(抗-HBs)均阴性的居民505人,分别按照0-1-6方案接种重组乙肝疫苗(CHO细胞)和重组(汉逊酵母)乙型肝炎疫苗。结果接种CHO乙肝疫苗后阳转率为96.22%,GMT为414.2 mIU/ml,汉逊乙肝疫苗分别为95.88%和383.3 mIU/ml,两种疫苗阳转率和抗体滴度均无统计学差异。接种者的年龄对免疫效果有影响,随年龄增长免疫效果下降。60岁以上的人群接种CHO乙肝疫苗后阳转率为87.0%,GMT为385.89 mIU/ml。结论成人接种同等剂量10μg的CHO和汉逊酵母乙肝疫苗后免疫效果相当,按年龄组比较,高年龄组人群接种CHO细胞乙肝疫苗免疫效果良好。
Objective To assess the effectiveness of different recombinant hepatitis B vaccine in adult population.Methods 505 healthy people aged over 20 years with negative HBsAg and anti-HBs were randomly selected.Rcombinant yeast-derived vaccine and CHO recombinant vaccine were vaccinated following 0,1,6months.Results In CHO recombinant vaccine group,the positive rate of anti-HBs is 96.22%,and the geometric mean titers were 414.2 mIU/ml.vs.the recombinant（Hansenule Polymorpha） hepatitis B vaccine group with 95.88% and 383.3 mIU/ml respectively.But there was no difference in the antibody titers and the positive rate between the 2 groups.The immunity effect was influenced by the age of inoculator,and showing decrease with the age increasing.An immunogenic advantage of CHO recombinant vaccine was suggested by the older then 60 years with antibody response 87.0%,and the geometric mean titers were 385.89 mIU/ml.Conclusions The immunity effectiveness with different hepatitis B vaccine made by recombinant DNA techniques in adult were perfect,no mater CHO recombinant vaccine or Recombinant（Hansenula Polymorpha）Hepatitis B Vaccine.An immunogenic advantage of CHO recombinant vaccine was suggested by the older people.
出处
《中国公共卫生管理》
2009年第6期653-654,共2页
Chinese Journal of Public Health Management
