转移相关基因CD_(44V6)在喉癌中表达及意义

Expressins of CD_(44) and its Significance in Laryngeal Carcinoma

[目的]研究转移相关基因CD_（44V6）在喉鳞癌中的表达及其临床意义。[方法]应用SP免疫组织化学方法研究48例喉鳞状细胞癌组织中CD_（44V6）的表达情况。[结果]CD_（44V6）阳性车在淋巴结转移组（87．50％）明显高于无淋巴结转移组（50．00％，P＜0．05）。在限鳞癌Ⅲ级（93．75％）明显高于鳞癌Ⅰ－Ⅱ级（46．88％，p＜0．01）。[结论]提示CD_（44V6）阳性的癌细胞具有转移的潜能，CD_（44V6）与喉鳞癌的颈淋巴结转移和低分化性密切相关。

[Purpose]To study the expression of CD44 gene in patients with laryngeal squamous cell carcinoma and its significance [Methods]Fourty－eight paraffin－ embeded laryngeal carcinoma tissues were studied by immunochemical Sp method [Results] Positive immunoreactivity of CD44V6was detected in 14 of 16 cases (87.50%)with lymph node involvement and in 16 of 32 cases (50.－－%)with no lymph node involvement, and it wasalso detected in 15 of 16(93.75%)poorly differentiated carcinoma (Ⅲ)cases and in 15 of 32(46.88%)well/moderately differentiated carcinoma(Ⅰ～Ⅱ)cases [Conclusions]The results suggest that CD44V6 positive carcinoma cells had the metastatic potency and the expression of CD44V6 wasclosely correlated with lymph node metastasis and the differentiation of carcinoma cells.z