原发性低颅压综合征10例临床分析

Clinical analysis of 10 cases of spontaneous intracranial hypotension syndrome

目的探讨原发性低颅压综合征的临床特点、发病机制、鉴别诊断、治疗及预后。方法回顾分析10例原发性低颅压综合征的临床资料。结果10例患者均有典型的体位性头痛,或伴有头晕、恶心、呕吐、耳鸣、视物模糊等,腰穿测CSF压力均低于70 mm H2O,脑脊液检查少数为血性,经过充分补液、加用苯甲酸钠咖啡因等治疗后均得到治愈。结论原发性低颅压综合征以体位性头痛为特征,结合腰穿测颅压可确诊,治疗包括充分补液、苯甲酸钠咖啡应用,其预后大多良好。

Objective To explore the clinical characteristics,pathogenesis,diagnosis,differential diagnosis、treatmen and prognosis of spontaneous intracranial hypotension syndrome.Methods Clinical material of 10 cases of spontaneous intracranial hypotension syndrome was retrospectively analysed.Results The 10 cases of patients all had typical postural headache,some accompanied by dizziness,nausea,vomiting,tinnitus and blurred vision.CSF pressures measured by lumbar puncture were under 70 mm H 2O.All were cured by full fluid replacement and administering caffeine sodium benzoate.Conclusion Spontaneous intracranial hypotension syndrome characterized by postural headache can be diagnosed by measurement of intracranial pressure with lumbar puncture.The treatment includs conducting full fluid replacement and applying caffeine sodium benzoate.Prognosis is good.