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食管鳞状上皮细胞癌细胞凋亡表达及其临床意义

Clinical Significance of the Expression of Apoptosis in Esophageal Squamous Cell Carcinoma
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摘要 目的探讨食管鳞状上皮细胞癌(食管鳞癌)中细胞凋亡的表达及其临床意义。方法应用末端脱氧核苷酸转移酶介导的dUTP缺口末端标记(TUNEL)法,研究人食管鳞癌细胞凋亡的表达水平。结果38例手术切除的食管鳞癌组织平均细胞凋亡指数ApoLI为12.10±5.13‰。角化型ApoLI高于非角化型(P<0.01);肿瘤分化越好,细胞凋亡越多,低度、中度、高度分化ApoLI有差异(P<0.05);不同性别、年龄、肿瘤部位、长度、深度,其ApoLI并无差异;以10‰为界将ApoLI分组绘制Kaplan-Meier生存曲线,ApoLI≥10‰组术后生存率高。结论细胞凋亡与原发食管鳞癌临床病理特征密切相关,并可用于食管鳞癌预后判断。 Objective To determine the clinical significance of the expression of apoptosis in esophageal squamous cell carcinoma. Methods Expressional level of apoptotic cell was detected in 38 operated esophageal squamous cell carcinoma(ESCC) by terminal deoxynucleotidyl transferase mediated dUTP nick end labeling (TUNEL) method. Results The mean apoptotic labeling index (ApoL I:‰ of TUNEL positive cells in carcinomatous cells) was 1210±513. Mean ApoL I of keratinizing types(1577±434) was significantly higher than those of nonkeratinizing types (803±170). The ApoL I increased from 651±058 with poorly differentiated cancers through 1058±290 with moderately differentiated cancers to 1841±449 with well differentiated cancers. There was no apparent correlation between ApoL I and sex, age, tumor size, tumor location and tumor infiltrative depth. The KaplanMeier survival curves between ApoL I<10‰ and ApoL I≥10‰ have significant difference, while the former has a shorter survival time. Conclusion The results suggest that apoptosis play an important role in progression of ESCC, and apoptosis may be a prognostic marker for ESCC therapy.
出处 《中国胸心血管外科临床杂志》 CAS 1998年第3期155-157,共3页 Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
关键词 细胞凋亡 TUNEL法 食管癌 鳞癌 预后 Esophageal squamous cell carcinoma Apoptosis TUNEL method
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