摘要
目的：评价薄层液基细胞技术（TCT）及Bethesda系统（TBS）对筛查临床宫颈病变的敏感性。方法：以组织学检测结果和HPVDNA检测结果为金标准，通过与传统巴氏细胞学比较，评价薄层液基细胞学对宫颈病变的筛查价值，阳性诊断包括意义不明的不典型鳞状细胞病变，所有检查均双盲进行。结果：HPV感染是宫颈癌发病的高危因素之一，HPV感染率与TBS分级的病变程度呈正相关，经x^2检验，ASCUS与LSIL、HSIL之间有极显著性差异（P〈0．01），其年轻化趋势值得注意。结论：对TCT检查发现异常的病例配合阴道镜病理检查和HPV—DNA检测进行最后的诊断，能有效防止对宫颈早期病变的遗漏。
Objective： To evaluate the thin- layer liquid -based cytology technique （TCT） and the Bethesda System （TBS） for screening for cervical lesions of clinical sensitivity. Methods ： The histological test results, and HPVDNA test results as the gold standard, by comparison with the traditional Pap cytology to evaluate liquid - based cytology for cervical disease screening values, including the significance of the positive diagnosis of atypical squalors cells of undetermined lesions, all inspections were carried out double blind. Results ： HPV infection is one of the risk factors for cervical cancer, HPV infection and TBS grade lesions was positively correlated by x^2 test, ASCUS and LSIL, HSIL among a very significant difference （P 〈0.01 ）, its getting younger and younger is worth noting. Conclusion： TCT examination revealed abnormal pathological examination of cases with colostomy and HPV - DNA testing for the final diagnosis, can effectively prevent early cervical lesions missed
