计算机重建白花前胡Ca^(2+)通道作用机制

RECONSTRUOTION OF Ca^2+ WHOLE CELL CLAMP AND STUDY OFP·PRAERUBTORUM DUNN ON Ca^2+ CHANNEL

本文根据Ｂｅｅｌｅｒ－Ｒｅｕｔｅｒ方程，对Ｃａ２＋通道电流结合膜片钳实验数据进行计算机重建，并研究了中药白花前胡有效成份Ｐｄ－ＩａＣａ２＋通道的作用模式，为研究Ｃａ２＋通道电流及开关因子的动态过程提供了一个新方法。

Abstract: According to Beeler-Reuter equation,we reconstruct action potental ionic currents and I-V curve combing with the experimental data of Ca^2+ whole cell clamp.we also study the P.Praerubtorum Dunn on Ca^2+ Channel.The results indicate that: 1.Pd-Ia as a Ca antagonists can shortenAPD,ERP,APD 20 and APD 50 absolutely but they can longen ERP relatively. 2.Pd-Ia as a Ca antagonists,subordinate to the similar law of effection and concentration:IC2+a(drug)/IC2+a=1ex-xhshere x=log C.when x=xh,IC2+a(drug)/IC2+a=0.5