心肌缺血在低氧和高温环境中的微循环效应

The effect of hypoxia and high temperature on the microcirculation in the state of myocardial ischemia in rabbits

目的探讨家兔在心肌缺血状态下在低氧和高温环境中的微循环反应。方法健康中国白兔20只,随机分为心肌缺血组和心肌缺血低氧高温组。心肌缺血低氧高温组,经缺血手术后将动物置于低氧高温环境[(42±0.5)℃,吸入氧含量为8.5%的氧]中,时间为30min。单纯心肌缺血组手术后放于室温(25℃)下30min,观察家兔肠系膜的微循环变化。结果心肌缺血对家兔肠系膜微循环影响不大(P>0.05),但是,心肌缺血加低氧和高温环境后可使家兔肠系膜微循环血管口径变大(P<0.05),血流速度变慢(P<0.01)。结论心肌缺血后,在低氧和高温的环境下可使微循环发生明显改变。

Objective To observe the effect of hypoxia and high temperature on the microcirculation in the state of myocardial ischemia in rabbits. Methods Twenty rabbits were randomly divided into the myocardial ischemia groups and the hypoxia and high temperature of myocardial ischemia groups, after myocardial ischemia, the hypoxia and high temperature of myocardial ischemia group were put into a hypoxia and high temperature state（42± 0. 5 ）℃, and inbreathed a mixture gas made of 8.5% oxygen and 91.5% nitrogen ） ,after 30 min,the rabbits were taken out of, and the changes of microcirculation of mesentery were observed. The rabbits of myocardial ischemia groups were taken out of roomtemperature （25℃ with 30 min）, and compared with the hypoxia and high temperature of myocardial ischemia group. Results In the myocardial ischemia group the microcirculation of mesentery in rabbits did not change significantly （ P 〉 0. 05 ）. But in the hypoxia and high temperature of myocardial ischemia group mesenteric microvessel expanded （P 〈 0. 05） and the speed of blood stream slowed down （ P 〈 0.01 ）. Conclusion After myocardial ischemia, hypoxia and high temperature can obviously change the microcirculation of mesentery in rabbits.